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Isle of Palms, SC 2+ Bedroom Vacation Rentals

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342 rentals found
43 Fairway Dunes by AvantStay | Coastal ...

43 Fairway Dunes on the Isle of Palms is ideal for getting away from it all with family and friends in search of a vacation that will make everybody happy. Located only two blocks from the beach, the freshly remodeled home features three bedrooms...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 6
BEST Resort Location! Oceanview! Communi...

The Seagrove community of well-maintained condominiums, lush greenery, and community pool is centrally located within walking distance of the Grandiose Pavilion, Conference Center, Villages, and Wild Dunes stores and eateries. This prime location is...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Private Pool, luxe interiors, 1-block to...

The Grace House – Coastal Elegance with Private Pool & Prime LocationTucked just behind the gates of Wild Dunes Resort, The Grace House is an chic, 5-bedroom, 4.5-bathroom getaway designed for fresh coastal living. With chic interiors, broad...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12
Grand Pavilion 120 - Premier Beachside E...

Welcome to Boardwalk at Grandiose Pavilion 120! $200 gift card special for remaining summer week stays Qualifying weeks are - June 1-6, June 13 - July 4th, July 15- Aug 18thThis bright and cavernous 3BR/3BA townhome sleeps 8 and is ideally located...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Oceanfront Shipwatch Wild Dunes - END UN...

Welcome to your dream vacation rental on Isle of Palms! This newly refreshed, beachfront villa in the Shipwatch community of Wild Dunes is an end-unit boasting beautiful ocean vistas and the ideal hideaway for families or groups of up to 8...

  • Isle of Palms
  • 3 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Pool, Spa, Ocean Views, One Block to Bea...

The Josephine House – Coastal Elegance Meets Laid-Back LuxuryWelcome to The Josephine House, a refined 4-bedroom, 4.5-bath sanctuary located along a calming street on Isle of Palms, just steps from the beach and close to the Isle of Palms Marina...

  • Isle of Palms
  • 4 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Stay @ After Dune Delight on Isle of Pal...

404 Summer House - After Dune DelightLocation: Isle of Palms, SCOverview:Welcome to 404 Summer House - After Dune Delight, a newly refreshed 2-bedroom, 2-bathroom vacation home located on the fourth floor, offering beautiful ocean vistas. This...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 5
Oceanfront Penthouse Condo - Pool & Dire...

$200 gift card for WEEK stays!Qualifying weeks are - June 20-27th, July 4-11th, July 25-Aug 1509 Summerhouse Villa, a charmingly appointed 2-bedroom, under new ownership and management! A 2-bathroom villa perched on the fifth floor of the exclusive...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 4
Premier, Modern Home with Pool! Great IO...

Welcome to Three Oaks!This Isle of Palms beach home is one of our most extravagant rental properties and is the ideal spot for your next vacation! Located less than 5 mins. walking to the beach via access paths at either 23rd or 25th Avenue, it...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 10
Sawyer by AvantStay | Stunning Isle Of P...

Welcome to Sawyer, an AvantStay home! Located on the gorgeous beachy Isle of Palms just 30 mins. away from downtown Charleston, this home is a amazing getaway for those looking for a calming spot a ideal distance from the action. Cook up some fresh...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 10
THE PEARL!  7bd/7ba IOP Home Private POO...

*Planning a winter beach escape? Stay in January or February 2027 and you can heat the pool for COMPLIMENTARY!*Introducing THE PEARL, one of our premier properties on the Isle of Palms! This cavernous Charleston-style home was refreshed in early...

  • Isle of Palms
  • 7 Bedrooms
  • 7 Bathrooms
  • Sleeps 20
Family-Friendly Wild Dunes Home Just Ste...

The Bella House – Timeless Lowcountry Charm Steps from the BeachTucked behind the gates of the Wild Dunes Resort and just a 5-min. walk to the beach, The Bella House is a 4-bedroom, 3.5-bathroom getaway designed for effortless coastal living. With...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
Modern and Elegantly Decorated House on ...

Exquisitely Decorated Modern House on a Quiet Street and 5 Min Walk to the Beach!Property HighlightsThree min. walk to the beachStunning updates and renovationsRoomy family homeChefs kitchenBooks, Toys and GamesThis is not your average vacation...

  • Isle of Palms
  • 4 Bedrooms
  • 3 Bathrooms
  • Sleeps 8
New Beach House Rental. Welcome to your ...

Welcome to your Isle of Palms Oasis!Get ready to fall in appreciate with this definitely striking, freshly remodeled 3-bedroom, 2-bathroom gem, making its grandiose debut on the short-term rental scene. With fresh ownership and a fresh perspective...

  • Isle of Palms
  • 3 Bedrooms
  • 2 Bathrooms
  • Sleeps 8
Private Pool + Rooftop Ocean Views

All Decked Out – Relaxed Coastal Luxury with Rooftop Ocean VistasWelcome to All Decked Out, a attractively designed Isle of Palms getaway where laid-back coastal living, broad outdoor spaces, and elevated beach home comfort create the ideal...

  • Isle of Palms
  • 5 Bedrooms
  • 5 Bathrooms
  • Sleeps 12
Beachfront, Pool Access, Balcony w/ Ocea...

Welcome to 222 D Shipwatch! This handsomely designed 2BDR condo is highlighted with a amazing oceanfront balcony, beach access, and a community pool! The interior of 222 D Shipwatch welcomes you with a bright, beachy ambiance. Prepare home-cooked...

  • Isle of Palms
  • 2 Bedrooms
  • 2 Bathrooms
  • Sleeps 6
Award-Winning Resort Amenities | Sandcra...

Sandcrab Court 18 by Wild Dunes4 Bedrooms | 2 Bathrooms | Sleeps 10 ________________________________________Welcome to Sandcrab Court 10, a impressive getaway on Isle of Palms’ exclusive Wild Dunes Resort. This roomy island getaway is great for...

  • Isle of Palms
  • 4 Bedrooms
  • 2 Bathrooms
  • Sleeps 10
Frank Sottile 8 Newly renovated

8 Frank Sottile | Permanent WavesLocation: Isle of Palms, SCOverview:This gorgeous home on the Isle of Palms was completely and luxuriously remodeled in 2024. Located in a calming getaway by a pond with idyllic vistas of the Harbor Course, this...

  • Isle of Palms
  • 5 Bedrooms
  • 4 Bathrooms
  • Sleeps 12